Welcome to Your Key West Home

Casa 325 is your home away from home on Key West’s Duval St.

Every one of our rooms and suites is unique and offers its own special Key West experience.

Contact us for expert help planning all your Key West activities — or just relax by our refreshing pool.  It’s all here for you at Casa 325, so book online today!

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About Us

Key West greeting sign

In the heart of Historic Old Town Key West, at 325 Duval Street, you will find Casa 325, a quaint Key West guesthouse with all the comforts of home. Don’t let the Duval Street address fool you. Though we are just steps away from some of the finest restaurants, shops, galleries, nightlife and activities on Duval Street and the Historic Key West Waterfront, Casa 325 Guesthouse is nestled away off the street, providing our guests the privacy they seek.